检索范围:
排序: 展示方式:
Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty
Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 177-180 doi: 10.1007/s11684-009-0021-x
关键词: vascular endothelial growth factors restenosis reactive oxygen species endothelial cells vascular smooth muscle cell
Role of nitric oxide in biological effects of vascular endothelial growth factor
Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 284-286 doi: 10.1007/s11684-009-0062-1
关键词: vascular endothelial growth factor nitric oxide N-nitro-L-arginine methyl ester vascular endothelial cells
Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG
《医学前沿(英文)》 2009年 第3卷 第2期 页码 164-170 doi: 10.1007/s11684-009-0038-1
关键词: epithelial-mesenchymal transition vascular endothelial cell growth factor matrix metalloproteinase-9 cyclooxygenase-2 higher microvascular density breast cancer
糖尿病发作后心脏脂蛋白脂肪酶的变化 Review
Chae Syng Lee, Yajie Zhai, Brian Rodrigues
《工程(英文)》 2023年 第20卷 第1期 页码 19-25 doi: 10.1016/j.eng.2022.06.013
由于心脏持续地收缩和舒张,需要大量的能量,其中脂肪酸(FA)是其三磷酸腺苷(ATP)的主要来源。但是,心脏无法制造这种底物,而是从多种来源获得脂肪酸,包括通过脂蛋白脂肪酶(LPL)的作用。脂蛋白脂肪酶在心肌细胞中产生,随后分泌到质膜上的硫酸乙酰肝素蛋白聚糖(HSPG)结合位点。然后为了将脂蛋白脂肪酶转移到内皮细胞管腔,糖基磷脂酰肌醇锚定的高密度脂蛋白结合蛋白1(GPIHBP1)与间质性脂蛋白脂肪酶结合,并将其转移到血管管腔,在那里脂蛋白脂肪酶可将循环中的甘油三酯分解为脂肪酸。内源性-β-葡萄糖醛酸酶乙酰肝素酶(Hpa)的独特之处在于,它是唯一已知的哺乳动物酶,可以裂解硫酸乙酰肝素,从而促进上述脂蛋白脂肪酶从心肌细胞HSPG中释放。在糖尿病中,一直认为心脏产生能量方式的改变是导致糖尿病性心肌病(DCM)的原因。糖尿病发展到中度后,随着葡萄糖利用率的降低,由于Hpa 作用的增强,心脏血管腔内的脂蛋白脂肪酶活性得到增强。虽然这种适应可能有助于补偿心脏对葡萄糖的利用不足,但从长期来看,它是具有毒性的,因为有害的脂质代谢物积聚,以及脂肪酸氧化增强和因此造成的氧化应激,最终导致细胞死亡。这与一种心脏保护生长因子——血管内皮生长因子B(VEGFB)的丧失同时发生。本文探讨了乙酰肝素酶、脂蛋白脂肪酶和血管内皮生长因子B之间的相互联系及其在糖尿病性心肌病中的潜在影响。鉴于缺乏基于机制的DCM治疗,了解这种心肌病的病理,以及脂蛋白脂肪酶的作用,将有助于我们推进其临床治疗。
Expression of PC-cell-derived growth factor in breast cancer
Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 426-430 doi: 10.1007/s11684-009-0085-7
关键词: PC-cell-derived growth factor breast neoplasms clinical markers
GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong
《医学前沿(英文)》 2007年 第1卷 第3期 页码 248-252 doi: 10.1007/s11684-007-0047-x
关键词: control stimulation mitogen-activated growth factor process
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
《医学前沿(英文)》 2023年 第17卷 第2期 页码 317-329 doi: 10.1007/s11684-022-0931-4
关键词: lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis
null
《医学前沿(英文)》 2017年 第11卷 第3期 页码 403-409 doi: 10.1007/s11684-017-0522-y
Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.
关键词: arterial thrombosis conditional knockout mice tissue factor pathway inhibitor vascular smooth muscle cells
Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction
LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi
《医学前沿(英文)》 2007年 第1卷 第2期 页码 196-199 doi: 10.1007/s11684-007-0037-z
关键词: endothelial resistin stimulation Incubation pathogenesis dysfunction
Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113
Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 357-362 doi: 10.1007/s11684-009-0046-1
关键词: carcinoma squamous cell pituitary tumor transforming gene (PTTG) protein basic fibroblast growth factor
Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 447-451 doi: 10.1007/s11684-009-0082-x
关键词: cervical cancer lymphatic vessel density blood vessel density platelet-derived growth factor
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 25-30 doi: 10.1007/s11684-013-0244-8
Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.
关键词: FGF21 metabolism pharmacology physiology clinical relevance
Current advances for bone regeneration based on tissue engineering strategies
Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian
《医学前沿(英文)》 2019年 第13卷 第2期 页码 160-188 doi: 10.1007/s11684-018-0629-9
关键词: bone tissue engineering stem cell bone scaffold growth factor bone regeneration
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 320-329 doi: 10.1007/s11684-016-0463-x
Coronary atherosclerosis is a major complication of chronic kidney disease. This condition contributes to the increased mortality in dialysis patients. p-Cresyl sulfate (PCS) is a prototype of protein-bound uremic toxins that cannot be efficiently removed through routine dialysis procedures. In the present study, ApoE−/− mice that underwent 5/6 nephrectomy were randomly divided into two groups, namely, vehicle-treated group (n = 20) and PCS-treated group (n = 20). Mice were sacrificed for en face and immunohistological analyses after 8 or 24 weeks of high-fat diet. Rat aortic vascular smooth muscle cells (VSMCs) were treated with phosphate buffer solution or 500 µmol/L PCS for in vitro evaluation. PCS-treated mice were observed to suffer increased atherosclerotic lesions after eight weeks of PCS administration. Moreover, 24 weeks of PCS administration also markedly increased the vulnerability index of aortic plaques. PCS was also observed to facilitate the migration and proliferation of VSMCs during the progression of the disease. Moreover, PCS disturbed the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases within the plaques. Thus, PCS played a vital role in promoting atherogenesis and disturbing the stability of formed plaques probably by targeting VSMCs.
关键词: p-cresyl sulfate atherosclerosis plaque stability vascular smooth muscle cell
An investigation on prevalent strategies for XFEM-based numerical modeling of crack growth in porous
《结构与土木工程前沿(英文)》 2021年 第15卷 第4期 页码 914-936 doi: 10.1007/s11709-021-0750-8
关键词: numerical modeling extended finite element method porous media crack growth stress intensity factor
标题 作者 时间 类型 操作
Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty
Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU
期刊论文
Role of nitric oxide in biological effects of vascular endothelial growth factor
Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,
期刊论文
Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer
Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG
期刊论文
Expression of PC-cell-derived growth factor in breast cancer
Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,
期刊论文
Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor-induced cell migration
GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong
期刊论文
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
期刊论文
Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis
null
期刊论文
Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction
LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi
期刊论文
Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113
Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,
期刊论文
The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis
Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,
期刊论文
Current advances for bone regeneration based on tissue engineering strategies
Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian
期刊论文
sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by targeting vascular
null
期刊论文